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  • 16 May 2025
  • Dr Boshi

Mounjaro vs Wegovy: Side Effects — What to Expect in 2025?

If you’re considering medical weight loss injections in 2025, chances are you’ve heard of Mounjaro and Wegovy. These two effective GLP-1 medications are helping thousands of people across the UK shed stubborn weight and take control of their health.

But one of the most important questions we get at 121 Clinic in Kempston, Bedford is:
👉 “What are the side effects — and how do they compare?”

In this guide, we break down what you need to know about Mounjaro vs Wegovy side effects, so you can make an informed, confident decision — or even better, come to our Open Day on Friday 30 May 2025 and get expert advice in person!


💉 How Do Mounjaro and Wegovy Work?

Both medications are part of a new class of weight loss drugs that work by mimicking natural hormones in your body to:

  • Reduce appetite

  • Slow digestion

  • Improve blood sugar regulation

Mounjaro (tirzepatide) affects GLP-1 and GIP receptors, while Wegovy (semaglutide) targets only GLP-1. This difference may affect how your body responds — and the type and intensity of side effects.


🔬 Common Side Effects: Mounjaro vs Wegovy

Side Effect Wegovy (Semaglutide) Mounjaro (Tirzepatide)
Nausea ✅ Common ✅ Common
Constipation ✅ Common ✅ Common
Diarrhoea ✅ Possible ✅ Possible
Loss of appetite ✅ Common ✅ Common
Headaches ⚠️ Sometimes ⚠️ Sometimes
Fatigue ⚠️ Sometimes ⚠️ Sometimes
Injection site pain ✅ Mild ✅ Mild
Dizziness ⚠️ Occasionally ⚠️ Occasionally
Reflux (GERD) ✅ Occasionally ⚠️ Less reported

🔍 Note: Side effects usually peak in the first few weeks and settle over time.


👩‍⚕️ Which Jab Has More Side Effects?

There’s no one-size-fits-all answer. Some patients find Mounjaro slightly more tolerable, while others prefer Wegovy. It often depends on:

  • Your gut sensitivity

  • Your hormone profile

  • Pre-existing conditions like diabetes or GERD

At 121 Clinic, we assess your health history to match you with the most suitable option.


How to Manage Side Effects

Here’s how we help patients minimise and manage side effects:

  • Start low and go slow: Gradual dose increases help your body adjust.

  • Stay hydrated: Dehydration can worsen nausea and dizziness.

  • Eat smaller meals: Focus on protein and low-fat, low-sugar foods.

  • Report symptoms early: We adjust your dose or timing if needed.


📍 Want Personalised Advice? Join Our Open Day in Bedford!

If you’re unsure which weight loss injection is right for you — or if side effects are a concern — we invite you to our Open Day at 121 Clinic in Kempston on Friday, 30 May 2025.

🩺 What’s included:

  • Free 10-minute assessment

  • Learn about Mounjaro vs Wegovy in person

  • Speak directly to our medical weight loss team

  • Ask questions in a private, no-pressure setting

📞 Call or WhatsApp 07785 587032 to book your free spot — spaces are limited!


Why Choose 121 Clinic in Kempston?

  • Personalised meal plans

  • Medically approved treatment

  • Clinically proven medication 

  • Science based weight loss in Bedfordshire

  • Local support in Kempston, Bedford— no national call centres


📌 Final Thoughts

Mounjaro and Wegovy are powerful tools — but they’re not magic pills. Understanding how they affect your body (and what to expect) is key to long-term success.

At 121 Clinic in Bedford, we’re here to guide you every step of the way — with honest advice, personalised care, and clinically approved weight loss solutions.


🔗 Ready to get started?

Visit 👉 www.121clinic.co.uk
Or book a FREE consultation on our Open Day: 📱 07785 587032